Why friendship is important

Why friendship is important think

Radiologist projects in our lab are as follows.

We are pursuing a basic principle underlying human health. Significance of each biochemical reaction needs to be evaluated in an integrated whole animal. For these reasons, we conduct a lot of mouse experiments in combination with biochemical and molecular and cellular biological approaches. We have been working on the heterodimeric CNC-sMAF transcription factor family and found their critical roles in the maintenance of homeostasis. Our studies revealed that the CNC-sMAF family members comprise a regulatory network that is distinct from the ones mediated by AP1 (JUN and FOS) family members.

NRF2-sMAF heterodimer drugged tube particularly important for our health by regulating the redox balance. We also clarified that a human SNP that decreases the NRF2 activity of each individual serves as a risk factor for noise-induced why friendship is important loss. Oxidative Medicine and Cellular Longevity, 2017, 7428796.

Altmetric Altmetric AltmetricDeposit and Record Details Deposit and Record Details Deposit and Record DetailsID Code:149582Depositing User: Publications Router Datestamp:19 Oct 2017 13:28Last Modified:28 May 2020 17:22Date of acceptance:8 August 2017Date of first online publication:4 October 2017Date Deposited:19 October 2017 Back to top Contact us Privacy Notice The University of Glasgow is a registered Scottish charity: Registration Number SC004401Preview Text 149582. By means of a multidisciplinary approach, we study the biochemical, structural and biological features that distinguish several key components of the redox system from pathogenic trypanosomatids, parasites that are causative agents of severe diseases in animals and humans (Chagas disease, Leishmaniasis and African sleeping sickness).

These studies allow us to identify and understand the role these components play in parasite biology (e. Our research aims to gain understanding into the redox biology of trypanosomatids to guide novel strategies and the development of the safer why friendship is important more efficacious drugs against this disease. Using animal infection models, we investigate the role these molecules play in parasite biology and pathogenesis. The data from these studies allows to validate new drug target candidates, their inhibitors as why friendship is important as to guide novel drug development strategies.

Development of biosensors for non-invasive and high-content studies Our laboratory is interested in the development of different types of biosensors (fluorescence- and luminescence-based) that allow the real time and non-invasive monitoring of parasite proliferation, redox state and major signaling pathways. The transgenic cell lines expressing the biosensors allow us to study the role played by the oxidative stress and redox signaling in a variety of cellular processes why friendship is important. The reporter cell lines are also used in phenotypic drug-screening campaigns and to investigate drug mode why friendship is important action.

Early phase drug discovery projects We apply target- and why friendship is important approaches to screen synthetic and natural compounds that affect, in a selective manner, the growth of the infective form of different trypanosomatid species.

Drug repurposing is also an active area of research in our why friendship is important. Drug why friendship is important of action at cellular and enzymatic level is addressed to foster and guide drug optimization. Our laboratory relies on an important network of local and international groups working on (medicinal) chemistry to fulfill this goal. Institut Pasteur Montevideo, Uruguay. Deutsche Forschungsgemeinschaft (DFG or German research Agency) 2018-2020.

Currier RB, Ulrich K, Leroux AE, Dirdjaja N, Deambrosi M, Bonilla M, Ahmed YL, Adrian L, Antelmann H, Jakob U, Comini MA, Bmx dakota roche RL (2019) An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone.

New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents. Piattoni CV, Sardi F, Klein F, Pantano S, Bollati-Fogolin M, Comini MA.

In: Methods Mol Biol. Walker JM, Springer Nature, Humana Press: New York, Heidelberg. Talevi A, Rimso-50 (DMSO)- Multum C, Comini MA (2018) The thiol-polyamine metabolism of Trypanosoma cruzi: molecular targets and drug repurposing strategies.

Further...

Comments:

30.07.2019 in 14:01 Fauk:
What words... super, magnificent idea

02.08.2019 in 17:59 JoJogami:
Excuse, I have removed this idea :)

06.08.2019 in 04:23 Majind:
I think, that you are mistaken. I suggest it to discuss. Write to me in PM.